Therapeutic Vaccines for HIV and Cancer: The Long Fox Memorial Lecture
Presented to the Bristol Medico Chirurgical Society at Bristol University 10.11.2010
Professor Angus Dalgleish
Professor of Oncology, St George’s Hospital,
University of London
Abstract (Full article in the WEMJ)
A classical vaccine approach to HIV vaccination has been elusive for many reasons. However, the fact that chimps and about 5% of humans who become infected do not progress to AIDS has raised the question of a vaccine to prevent disease progression and not necessarily infection. Targeting the bits of the virus that stimulate the disease process is theoretically possible and a vaccine along these lines is under preparation for clinical trials. Therapeutic vaccines are also used in cancer and the first one "provenge" has just been approved by the FDA for use in advanced prostate cancer. Many more are in development. Recent research suggests that certain drugs can enhance the effect of vaccines and the most impressive candidates for this are the thalidomide derived IMiDS such as Revlimid(Lenolidomide) and Pomalidomid.
key words HIV, therapeutic vaccine, C5gp120, Graft versus host disease, cancer vaccines for prostate, lung, melanoma, etc, Immunomodulatory drugs, Revlimid/lenalidomide, Pomalidomide.